BIOGRAPHICAL SKETCH

Dr. XIFENG WU

 

 

NAME

XIFENG WU

POSITION TITLE

ASSOCIATE  PROFESSOR

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

 

INSTITUTION AND LOCATION

DEGREE

(if applicable)

 

YEAR(s)

 

FIELD OF STUDY
Shanghai Medical University, China

Zhejiang Medical University, China

UT School of Public Health, Houston, TX

M.D.

M.S.

Ph.D.

1984

1987

1994

Medicine

Occupational Health

Epidemiology

Professional Experience:

1987 - 1990        Research Associate, Institute of Industrial Hygiene and Occupational Diseases, Zhejiang

Academy of Medical Science, China

1990 - 1991        Post Doctoral Fellow, National Laboratory of Industrial Environment and Risk Analysis

(INERIS), Division of Occupational Health, France

1991 - 1994        Graduate Research Assistant, The University of Texas M.D. Anderson Cancer Center,

Department of Cell Biology, Houston, TX

1995 - 1995        Research Associate of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Department of Epidemiology, Houston, TX

1995 - 2000        Assistant Professor of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Department of Epidemiology, Houston, TX

1995 - 2000        Assistant Professor of Biological Science, The University of Texas School of Public Health, Houston, TX

2000 - present      Associate Professor of Epidemiology, UT M.D. Anderson Cancer Center, Department of Epidemiology

2001 - present      Associate Professor of Epidemiology, UT Graduate School of Biomedical Sciences

2000 - present      Associate Professor of Epidemiology, The University of Texas School of Public Health, Houston, TX

 

Honors and Awards:

1989                      Zhejiang Scientific and Technologic Advance Award

1993                 D. Jack Kilian Scholarship, The University of Texas School of Public Health, Houston, TX

1995                      Richard C. Devereaux Award in Lung Cancer Prevention, Cancer Research Foundation of America

2002        Faculty Scholar Award, The University of Texas M.D. Anderson Cancer Center,Houston, TX

 

Selected Publications: (From a total of 73 peer reviewed publications, 3 invited publication and 7 book chapters)

Hazra A, Grossman HB, Zhu Y, Luo S, Spitz MR, WuX.  Benzo[a]pyrene diol epoxide-induced 9p21 aberrations associated with genetic predisposition to bladder cancer.  Gene Chromosome & Cancer (in press).

Gorlova O, Amos C, Henschke C, Lei L, Spitz M, Wei Q, Wu X, Kimmel M. Genetic susceptibility for lung cancer: Interactions with gender and smoking history and impact on early detection policies. Human Heredity (in press).

Zheng L, Wang Y, Schabath MB, Grossman HB, Wu X. Sulphotransferase (SULT) 1A1 polymorphism and bladder cancer risk: A case-control study.  Cancer Letters (in press).

Wang Y, Liang D, Spitz MR, Zhang K, Dong Q, Amos CI, Wu X.  XRCC3 genetic polymorphism, smoking, and lung cancer risk in minorities.  Cancer (in press).

Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK, Spitz MR. Telomere Dysfunction: A Cancer Predisposition Factor?  Journal of the National Cancer Institute 2003; 95(16):1211-8.

Wu X, Tortolero GL, Zhao H, Phatak D, Spitz MR, Follen M. Serum levels of insulin-like growth factor-I and risk of squamous intraepithelial lesions of the cervix.  Clinical Cancer Research 2003; 9 (9):3356-61.

Wang Y, Spitz MR, Zhu Y, Dong Q, Shete S, Wu X.  From genotype to phenotype:  Correlating XRCC1 polymorphisms with mutagen sensitibity.  DNA Repair 2003; 2(8):901-8.

Do KA, Johnson MM, Doherty DA, Lee JJ, Wu XF, Dong Q, Hong WK, Khuri FR, Fu KK, Spitz MR. Second primary tumors in patients with upper aerodigestive tract cancers: joint effects of smoking and alcohol (United States). Cancer Causes Control 2003; 14(2):131-8.

Park SJ, Zhao H, Spitz MR, Grossman HB, Wu X. An association between NQO1 genetic polymorphism and risk of bladder cancer. Mutation Research 2003; 536(1-2):131-7.

Hazra A, Chamberlain RM, Grossman HB, Zhu Y, Spitz MR, Wu X. Death receptor 4 and bladder cancer risk. Cancer Research 2003; 63(6):1157-9.

Wu X, Zhao H, Wei Q, Amos CI, Zhang K, Guo Z, Qiao Y, Hong WK, Spitz MR. XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity. Carcinogenesis 2003; 24(3):505-9.

Wang Y, Spitz MR, Schabath MB, Hong WK, Wu X. Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study. Lung Cancer 2003; 40(1):25-32.

Schabath MB, Spitz MR, Grossman HB, Zhang K, Dinney CP, Zeng P, Wu X.  Genetic instability in bladder cancer assessed by the comet assay.  Journal of the National Cancer Institute 2003; 95(7):540-7.

Zhao H, Grossman HB, Spitz MR, Lerner SP, Zhang K, Wu X. Plasma levels of insulin-like growth factor-1 and binding protein-3 and their association with bladder cancer risk.  Journal of Urology 2003; 169(2):714-7.

Zhang H, Spitz MR, Tomlinson GE, Schabath MB, Minna JD, Wu X.  Modification of lung cancer susceptibility by green tea extract as measured by the comet assay.  Cancer Detection and Prevention 2002; 26:411-8.

Spitz MR, Barnett MJ, Goodman GE, Thornquist MD, Wu X, Pollak M. Serum insulin-like growth factor (IGF) and IGF-binding protein levels and risk of lung cancer: A case-control study nested in the β-Carotene and retinol efficacy trial cohort. Cancer Epidemiology Biomarkers and Prevention 2002; 11:1413-8.

Zhu Y, Spitz MR, Strom S, Tomlinson GE, Minna JD, Wu X.  A case-control analysis of lymphocytic chromosome 9 aberrations in lung cancer.  International Journal of Cancer 2002; 102: 536-40.

Zhu Y, Spitz MR, Hsu TC, Wu X.  Genetic instability of specific chromosomes associated with a family history of cancer. Cancer Genetics and Cytogenetics 2002; 136(1):73-7.

Chang S, Wu X., Yu H., Spitz MR. Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors. Cancer Epidemiology Biomarkers and Prevention 2002; 11:758-66.

Zhu Y, Spitz MR, Zheng Y, Hong WK, Wu X. BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma. Cancer 2002; 95(3):563-8.

Schabath MB, Spitz MR, Delclos GL, Gunn GB, Whitehead LW, Wu X. Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk. American Journal of Industrial Medicine 2002; 42(1):29-37.

Schabath MB, Spitz MR, Hong WK, Delclos GL, Reynolds WF, Gunn GB, Whitehead LW, Wu X. A myeloperoxidase polymorphism associated with reduced risk of lung cancer. Lung Cancer 2002; 37:35-40.

Wu X, Lippman SM, Lee JJ, Zhu Y, Wei QV, Thomas M, Hong WK, Spitz MR. Chromosome instability in lymphocytes: A potential indicator of predisposition to oral premalignant lesions. Cancer Research 2002; 62(10):2813-8.

Wu X, Zhao H, Amos CI, Shete S, Makan N, Hong WK, Kadlubar FF, Spitz MR. p53 genotypes and haplotypes associated with lung cancer susceptibility and ethnicity. Journal of the National Cancer Institute 2002; 94(9):681-90.

Zhao H, Spitz MR, Gwyn KM, Wu X.  Microsomal epoxide hydrolase polymorphisms and lung cancer risk in non-hispanic Whites. Molecular Carcinogenesis 2002; 33(2):99-104.

Wang Y, Spitz MR, Tsou A, Zhang K, Makan N, Wu X. Sulphotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: Aa case-control analysis. Lung Cancer 2002; 35(2):137-42.

Buchholz TA, Wu X, Hussain A, Tucker SL, Mills GB, Haffty B, Bergh S, Story M, Geara FB, Brock WA. Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. International Journal of Cancer 2002; 97(5):557-61.

Zhu Y, Spitz MR, Lei L, Wu X.  A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Cancer Research 2001; 61(21):7825-9.

Zhao H, Spitz MR, Tomlinson GE, Zhang H, Minna JD, Wu X. g-Radiation-induced G2 delay, apoptosis, and p53 Response as potential susceptibility markers for lung cancer. Cancer Research 2001; 61(21):7819-24.

Wu X, Gwyn K, Amos CI, Makan N, Hong WK, Spitz MR. The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and Mexican-Americans. Carcinogenesis 2001; 22(6):923-8.

Spitz MR, Wu X, Wang Y, Wang L, Shete S, Amos CI, Guo Z, Lei L, Mohrenweiser H, Wei Q.  Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.  Cancer Research 2001; 61(4):1354-7.

Buchholz TA, Wu X. Radiation-induced chromatid breaks as a predictor of breast Cancer Risk. International Journal Of Radiation Oncology, Biology, Physics 2001; 49(2):533-7.

de Andrade M, Spitz MR, Wu X, Liang JC, Strom SS. Statistical models for analysis of cytogenetic biomarkers. Journal of Investigative Medicine 2000; 48(4):281-6.

Wu X, Hudmon KS, Detry MA, Chamberlain RM, Spitz MR. D2 dopamine receptor gene polymorphisms among African-Americans and Mexican-Americans: a lung cancer case-control study. Cancer Epidemiology, Biomarkers and Prevention 2000; 9:1021-6.

Spitz MR, Duphorne CM, Detry MA, Pillow PC, Amos CI, Lei L, de Andrade M, Gu X, Hong WK, Wu X.  Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiology, Biomarkers and Prevention 2000; 9:1017-20.

Wu X, Yu H, Amos CI, Hong WK, Spitz MR. Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk.  Growth Hormone & IGF Research 2000; Suppl A:S26-7.

Zhang H, Buchholz TA, Hancock D, Spitz MR, Wu X.  g-radiation-induced single cell DNA damage as a measure of susceptibility to lung cancer: A preliminary report.  International Journal of Oncology 2000; 17(2):399-404.

Schabath MB, Spitz MR, Zhang X, Delclos GL, Wu X.  Genetic variants of myeloperoxidase and lung cancer risk.  Carcinogenesis 2000; 21(6):1163-6.

Wu X, Yu H, Amos CI, Hong WK, Spitz MR. Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk.  Journal of the National Cancer Institute 2000; 92(9):737-43.

Vulimiri SV, Wu X, Baer-Dubowska W, de Andrade M, Detry M, Spitz MR, DiGiovanni J.  Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo-2’-deoxyguanosine in lymphocyte DNA from a case-control study of lung cancer involving minority populations. Mol Car 2000; 27:34-46.

Spitz MR, Detry MA, Pillow P, Hu Y, Amos CI, Hong WK, Wu, X. Variant alleles of the D2 dopamine receptor gene and obesity. Nutrition Research 2000; 20(3):371-380.

Abdel-Rahman SZ, Soliman AS, Bondy ML, Wu X, El-Badawy SA, Mahgoub KG, Ismail S, Seifeldin IA, Levin B.  Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt. Cancer Letters 1999; 142:97-104.

Gu J, Spitz MR, Yang F, Wu X.  Ethnic differences in poly (ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk.  Carcinogenesis 1999; 20(8):1465-9.

Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X.  Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis.  Journal of the National Cancer Institute 1999; 91(2):151-6.

Gu J, Bondy ML, Sigurdson A, Spitz MR, Hsu TC, Wu X.  Three measures of mutagen sensitivity in a cancer-free population.  Cancer Genetics and Cytogenetics 1999; 110:65-9.

Wu X, Kemp B, Amos CI, Honn SE, Zhang W, Walsh GL, Spitz MR. Associations among telomerase activity, p53 protein overexpression, and genetic instability in lung cancer.  British Journal of Cancer 1999; 80:453-7.

Lin H, Bondy ML, Langford LA, Hess KR, Delclos GL, Wu X, Chan W, Pershouse MA, Yung WKA, Steck PA.  Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance. Clinical Cancer Research 1998; 4:2447-54.

Wu X, Zhao Y, Kemp BL, Amos CI, Siciliano MJ, Spitz MR. Chromosome 5 aberrations and genetic predisposition to lung cancer. International Journal of Cancer 1998; 79:490-3.

Wu X, Gu J, Hong WK, Lee JJ, Amos CI, Jiang H, Winn RJ, Fu KK, Cooper J, Spitz MR. Benzo[a]pyrene diol epoxide and bleomycin sensitivity and susceptibility to cancer of upper aerodigestive tract. Journal of the National Cancer Institute 1998; 90(18):1393-9.

Wu X, Gu J, Amos CI, Jiang H, Hong WK, Spitz MR. A parallel study of in vitro sensitivity to benzo[a]pyrene diol epoxide and bleomycin in lung carcinoma cases and controls.  Cancer 1998; 83:1118-27.

Wu X, Zhao Y, Honn SE, Tomlinson GE, Minna JD, Hong WK, Spitz MR. Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer.  Cancer Research 1998; 58:1605-8.

Wu X, Gu J, Patt Y, Hassan M, Spitz MR, Beasley RP, Hwang LY.  Mutagen sensitivity as a susceptibility marker for human hepatocellular carcinoma.  Cancer Epidemiology, Biomarkers and Prevention 1998; 7:567-70.

Spitz MR, Shi H, Yang F, Hudmon KS, Jiang H, Chamberlain RM, Amos CI, Wan Y, Cinciripini P, Hong WK, Wu X.  A case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients.  Journal of the National Cancer Institute 1998; 90:358-63.

Wu X, Hsu TC, Cao S, Lee JJ, Amos CI, Spitz MR. Deletion in poly(ADP-ribose) polymerase pseudogene and lung cancer risk. Carcinogenesis 1998; 19(1):93-8.

Wu X, Amos CI, Kemp BL, Shi H, Jiang H, Wan Y, Spitz MR  Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations.  Cancer Epidemiology, Biomarkers and Prevention 1998; 7:13-8.

Wu X, Dave BJ, Jiang H, Pathak S, Spitz MR. Lung carcinoma patients with a family history of cancer and lymphocyte primary chromosome 9 aberrations.  Cancer 1997; 79:1527-32.

Wu X, Shi H, Jiang H, Kemp B, Hong WK, Delcos GL, Spitz MR.  Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer.  Carcinogenesis 1997; 18(5):967-73.                         

           King TM, Trizna Z, Wu X, Amos CI, Fueger RH, Fueger JJ, Fritsche HA, Hsu TC, Winn R, Spitz MR. A clinical trial to evaluate the effect of vitamin C supplementation on in Vitro mutagen sensitivity.  Cancer Epidemiology, Biomarkers and Prevention 1997; 6:537-42.         

Wu X, Hsu TC, Spitz MR. Mutagen sensitivity exhibits a dose-response relationship in case-control Studies.  Cancer Epi Bio & Prev 1996; 5:577-8.

           Spitz MR, Wu X, Jiang H, Hsu TC.  Mutagen sensitivity as a marker of cancer susceptibility.  Journal of Cellular Biochemistry 1996; 25S:80-4.

           Wu XF, Spitz MR, Delclos GL, Connor TH, Zhao Y, Siciliano MJ, Hsu TC.  Survival of cells with bleomycin-induced chromosomal lesions in the cultured lymphocytes of lung cancer patients.  Cancer Epidemiology, Biomarkers and Prevention 1996; 5:527-32.

Hsu TC, Wu X, Trizna Z.  Mutagen sensitivity in humans: A comparison between two nomenclature systems for recording chromatid breaks.  Cancer Genetics and Cytogenetics 1996; 87:127-32.

Wu X, Hsu TC, Annegers JF, Amos CI, Fueger JJ, Spitz MR. A case-control study of nonrandom distribution of bleomycin-induced chromatid breaks in lymphocytes of lung cancer cases.  Cancer Research 1995; 55:557-61.

Spitz MR, Hsu TC, Wu X, Fueger JJ, Amos CI, Roth JA.  Mutagen sensitivity as a biologic marker of lung cancer risk in African Americans.  Cancer Epidemiology, Biomarkers and Prevention 1995; 4:99-103.

Wu X, Delclos GL, Annegers JF, Bondy ML, Honn SE, Henry B, Hsu TC, Spitz MR. A case-control study of wood-dust exposure, mutagen sensitivity, and lung-cancer risk.  Cancer Epidemiology, Biomarkers and Prevention 1995; 4:583-8.

Jin X, Wu X, Roth JA, Amos CI, King TM, Branch C, Honn SE, Spitz MR.  Higher lung-cancer risk for younger African Americans with the Pro/Pro p53 genotype.  Carcinogenesis 1995; 16(9):2205-8.

Strom SS, Wu X, Sigurdson AJ, Hsu TC, Fueger JJ, Lopez J, Tee PG, Spitz MR. Lung cancer, smoking patterns, and mutagen sensitivity in Mexican-Americans. Journal of the National Cancer Institute (Monograph) 1995; 18:29-33.

Wu X, Zhang QF.  A review on the combined effects of mixed dusts.  J Labor Med 1990; 7:45-7 (in Chinese).

Wu X, He LR, Hong CF. Preventive efficacy of a Chinese traditional medicine anti-silicosis tablet on silicosis. 1990; Zhejiang Acad Med Sci.

Wu X, Hong CF. Application of the method of measuring cellular ATP on the research of pneumoconiosis.  J Occ Med 1990; 17:231-2.

Wu X, Zhang QF.  The effect of zinc on the alveolar macrophage cytotoxicity due to nickel-coal dust.  Chinese Med J 1990; 103:754-8.